First of all, thank you for your reply!
In the old system (a Lenovo G45-50 laptop), I only had this one SATA SSD inside (no 2nd HDD/SSD connected), so I think that means the answer is Yes.
Currently, in the new system (MSI PRO B660-A), I have an NVME SSD in M2_1 slot, and the 2.5'' SATA SSD...