Yes i/o is a potential problem tho if rly necssry, wireless option's could be implemented for most conceivable requirements.
I definitely like the completely passive case is a heatsink line of thought. You could change the whole construction of a case with this in mind.
Building a pc case to suit tough environments means looking at case building from a whole new perspective.
One of the best concepts I've seen yet is a rather large case tested by Linus Tech Tips.
It used a very conventional flow through system with some very unconventional extras.
Basically it...