I just built a system around this board with a Ryzen 5 5600x and so far it's been perfectly stable. I had to update the BIOS and Ethernet drivers before I could maintain an internet connection but that's the only issue I've had. I'm another who purchased this in large part because it has 8...
I've been using the non-windowed versions of the Define series since the R3 for small and quiet media server builds. The loss of two 3.5" bays is a deal killer for me. I guess I'll be looking for a new server case. Bummer...I really liked these cases.