I have a similar set up:
MSI N660TI-2GD5/OC GeForce GTX 660 Ti
Intel Core i5 - 3570K
GIGABYTE GA-Z77X-UP4 TH
I have also managed to get connected to my Apple Thunderbolt display using Virtu. I am not sure how stable this is yet and I cannot answer the question about using the discrete card...
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