Should have little to no issues with that setup. I personally found SLI 970's to run perfectly fine on swift, so a pair of 980s should be even better.
290x is better for the money if talking strictly by raw performances, but game support on AMD's part, from what I have seen, is poorer than nVidia's, for all that is worth. I found there were a few recent games that are playable on nVidia cards but not on AMD, and I have not seen any recent titles where it is the otherway round. There were games that did better with AMD cards, but not to the point where it is unplayable on nVidia.