2666MHz DDR3 RAM will work with most DDR3 motherboards, even if it's above the supported limit. All you need to do is activate the XMP profile (EOCP or DOCP on AMD boards). Technically this is overclocking so it's not officially supported on the mobo, but it works fine.
EDIT: Sometimes you'll need to raise northbridge or IMC voltage a little bit to get high speed RAM to work, depending on the mobo and CPU.
RAM frequency makes very little difference in real world applications, except when using an iGPU.