2 slim optical drives in 5.25" bay

Solution
Yes, though you'll need slimline SATA to normal SATA + power adapters - that comes with IDE adapters, which won't work.

You might also find you're running short of SATA ports.

What do you need that many bays for?
Well I have enough sata ports. I'm using CM Cosmos II, 1 bay for optical drive, 1 for fan controler, 1 for sd cards etc, X doc for reservoir.
Can't I just use normal sata cables?