I wouldn't push it with two GTX 295s. You may be able to power 3 GTX 275s, but definitely consider a higher wattage PSU for four GPUs. Corsair makes a great 1KW PSU. I think it's the HX1000W.
But before we get too carried away, lets consider the rest of your system. Without know your system specs and monitor/resolution you game at. Upgrading could be pointless and the gains very marginal if your system won't allow you to utilize the extra GPU power. Even with an overclocked i7 to 3.7GHz, you will have a CPU limitation with 2 GTX 295s, even at 1920x1200.