Yes.
Source:
http://www.watergarden.org/site/Filter_index.html
"Filter options up to 500 gallons" noted. i.e., no exclusions for less than "X" gallons.
And I would expect other factors such as surface area, depth, location, would have an impact - the objective is clean habitable water for the fish. Yes on that alone.
Nothing to do with computers per se, I know. But my curiousity about things in general just takes over......