It's not really a point of contention as to does it make a difference, if it's moving 1 pixel, it make a difference. The question is how much of a difference ? My way of looking at it is, it's sitting there doing nothing, why not use it ?
And, of course, what you are doing will make a difference ... my kids have their chat apps open, I always have several spreadsheets and browser tabs open and sometimes I'm looking at a walkthru or instructional youtube video say for example In-Game apps that I have written, a quest walkthru or whatever. The more pixels that are moving, the greater the impact. If its just MSI AB logging and the chat app, won't likely be even measurable.
But I I never did finish what I was thinking of while I was talking on phone w/ kid who needs "daddy taxi" ... those nagging mismatched refresh rate issues mentioned above are a non factor.... for example:
My son plays a game w/ the two GFX cards in SLI at 165 hz refresh rate using G-Sync on an Acer predator XB271HU (3 ms combined lag / 4.5 ms **real** average response time) or perhaps he turned off G-Sync and is using 120 hz w/ ULMB for the game ... do we really wanna drive the old slow 60 MHz Dell IPS 2nd monitor w/ 25ms response time from that same pair of cards ?