With a quality rad and fans, an internally mounted 360mm should be plenty for 2 cards and a cpu.
I've got a very good externally mounted 120mm rad with a single fan that used to cool both OC'd cpu and gpu just fine.
You could get creative with a 240 and run 3-4 fans in pull config with a shroud. Always use dust filters on the rads too, will save you from having to get in there with a blower or vac in 6 months.