Nope:
PCPartPicker Part List
CPU: AMD Ryzen 9 3900X 3.8 GHz 12-Core Processor ($434.00 @ Amazon)
Motherboard: Asus TUF GAMING X570-PLUS ATX AM4 Motherboard ($179.99 @ B&H)
Memory: G.Skill Trident Z RGB 32 GB (2 x 16 GB) DDR4-3600 Memory ($174.99 @ Newegg)
Storage: Crucial MX500 1 TB 2.5" Solid State Drive ($114.99 @ Adorama)
Video Card: NVIDIA GeForce RTX 2080 Ti 11 GB Founders Edition Video Card ($1199.99 @ Best Buy)
Case: Lian Li PC-O11 Dynamic ATX Full Tower Case ($144.99 @ Adorama)
Power Supply: SeaSonic FOCUS Plus Gold 750 W 80+ Gold Certified Fully Modular ATX Power Supply ($138.93 @ Newegg)
Total: $2387.88
Prices include shipping, taxes, and discounts when available
Generated by PCPartPicker 2020-04-22 22:08 EDT-0400
Add on to that - for simplicity's sake, a kit from EK, like this one:
https://www.ekwb.com/shop/ek-kit-classic-rgb-s360 (353.79USD)
You'll still have to purchase a gpu water block and fittings for it, because they're not included - at least 130USD there.
I could see it riding pretty close to 3K.
And that's only a single 360mm rad, which may be insufficient for both cpu amd gpu. So add another rad, fans and fittings for about 150. And that's using cheaper fans(ie not ek or noctua) like xspc. A 3 pack of xspc fans are about 35, not great fans but they work. I have 5 of them total. Not the quietest but they definitely do the job fine.
If you dont grab the kit listed above and piece it together, plan on more $$$. My loop using a mix of ek/xspc and others was probably around 800ish. That's also not a d5 or ddc pump, but a more generic xspc. I'd recommend a d5 or ddc, but will say zero issues with my xspc. And again performance is great.
CPU block-70ish
GPU block-100-150, backplate may be another extra cost if not included. Ek requires a separate backplate-45.
2x 360mm rads-100ish
6x fans- high quality noctua(25x6=150). Xspc or similar-80ish
Fittings-50+. Assuming all straight. Start adding 45 or 90 degree fittings and start adding 3-5 per fitting. Adding a drain valve, another 10-30. Tubing and coolant is the cheapest part, say 50 total at the upper end. Possibly as cheap as 20 if you can live with soft. Buying from multiple suppliers, consider multiple shipping prices.
If in the US, look at performancepcs. They'll have it all, a one stop shop. At least you'll be able to do one shipping charge.
So those parts and 2500, no not possible. Even with a 2080s.