Beyond 4GHz actually rarely makes a difference either currently for most games.
As for FOUR YEARS from now, the biggest difference will be better use of all eight threads, as well as the graphics card of course.
As for WHICH BOARD, I suggest you look at CUSTOMER REVIEWS to get an idea of quality as your main focus. My recommendations are either that GIGABYTE or the ASUS from that list.
I've been recommending the Asus Maximus Hero VI which is a great board, and has SupremeFX audio. If you were to buy a sound card anyway there's no difference in price (may even be cheaper).
The HERO is only $36 more than the MSI you linked, and I personally think it's worth the difference in price.
http://pcpartpicker.com/part/asus-motherboard-maximusvihero