The difference between the 4350 and the 4650 is substantial. The 4650 has 4 times the amount of steam processors and uses GDDR3 no GDDR2 which is FAR better. You wont do much gaming with a 4350, but a 4650 is basically the lowest card that can be considered a gaming card on the market. The 4650 is very similar, in performance, to the 8800 GTS 320mb.