I like the idea, the only issue that I can see is that exhausting lots of heat outside the case is not as good as not producing lots of heat to begin with
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If this was to be used as a HTPC, for example, it could potentially be placed in an enclosed cupboard with a glass front so IR remotes can be used, but heat exhausted from the case would just build up in the cupboard and the ambient temperature would overwhelm whatever cooling solution you used
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Sat on a desk, fine, sat in a cupboard, not fine