There are so many reasons for this problem it can make your head spin.
Any indication of a power surge/brownout problem during the time you were gone?
I'm assuming you've disconnected any other drive from the system other than the boot drive of course. If you haven't done so, do it.
I'm assuming you're unable to access the BIOS/UEFI.
The very first potential culprit, of course, is your boot drive. The most practical troubleshooting step at this time is to connect the SSD as a secondary drive in another PC and determine if it's detected. If so, test it with the Samsung Magician program. Based on our experience with at least a score of Samsung SSDs it's unlikely that's the problem - but, of course, it's possible.
Check your PC to determine all the connections are proper & secure.
If you're unable to isolate the problem your only practical recourse is to "start over" as it were. Rebuild your PC on a step-by-step basis.
Remove all your components (including all drives) excepting the MB, CPU, RAM, Graphics card, keyboard & mouse, & PSU. Reconnect your A/C cord and power on the system.
What happens? Do you get a "normal" screen display? No error messages or strange notations?
Can you access your BIOS/UEFI without any difficulty at this point and review the CMOS-BIOS settings? Check the hardware monitor/PC Health in the BIOS to determine that all temps are within normal range?
It's conceivable the PSU may be defective. Unfortunately the only definitive way to tell is to substitute another PSU, although if you have a PSU power tester that might provide the answer.
And finally, a defective motherboard. Again, only a substitution will definitively determine if that component is the problem.
Assuming all is well at this point leave the system powered on for the next hour or so, checking to see if anything untoward shows up.
Should all appear well at this point this is an indication that there's nothing wrong with the basic components of your system. While not absolutely definitive this is so, it's a very strong indication that something else is amiss.
Hopefully you'll discover the problem (and more importantly, the remedy) long before the above steps.
Keep us informed of your progress (or lack thereof).