There's been talk of lower TDP versions. If a version with less cores/CUs gets down to the ~28-45W range, then you're around where MSI Claw, Lenovo Legion GO, ROG Ally, etc. are. And maybe these handhelds are all way too power hungry, but there is a market for it.
Only one 8-core chiplet is needed. The 256-bit memory bus is the star of the show.
It will definitely end up in mini PCs from vendors like Minisforum. That's a growing segment and buyers can accept some of the disadvantages (soldered CPU on board, likely soldered memory, relatively high price).
I think it's too physically large to even fit on AM5.
Strix Halo information leaked a long time ago, and it has started to appear in Linux code. It's coming, hopefully. Problem is it can't be all things for all people. It's primarily intended for high-end laptops. In pre-built mini PCs, it might be good but CPU + GPU combos will easily defeat it if it's too expensive. It's not viable for handhelds unless a relaxed version with only 6-8 cores but the full 256-bit memory can get enough battery life.
In laptops it has the potential to achieve better efficiency in a smaller chassis than the laptop APU + dGPU combos it would be competing with. It might be able to command a higher price, but it would look great if it's cheaper.