Ideally yes.
Make it a definitive yes if you wear synthetic fiber clothes, polyester, cotton/ poly blends; are not extremely situationally aware and not very mindful to ground yourself after every move; work space is on carpet, vinyl composite tiles (VCT) vinyl sheet flooring (frequently confused with linoleum) or in presence of high voltage devices.
You can chance it if you answer no to all the above. Have a earth ground metal surface to discharge yourself after every move, before touching the components, and as you are moving to assemble them. Are not in an environment that has less than 60% relative humidity.
No, if you are destroying your equipment on purpose.
Practically as die lithography gets smaller, 14nm currently it takes...