the "cure" time is different for every paste and cpu and cooler setup. and its not really a set 50 hours or 200 hours. its a heat up and cool down cycle. heat makes metals, copper in this case, stretch and contract. on the microscopic level, as the top of the cpu heats up faster and is at a different temp then the bottom of the cooler, the two literally slide against each other, and stretch and contract against each other. think of it as how fault lines works for an earthquake, except in this case as they cool down the return to their previous position. as they slide against each other, the thermal paste gets pushed around and eventually finds the valleys and gaps that are full of air, on a microscopic level, and fills them in.
metal on metal does a better job of transferring heat than the thermal paste. but air does a bad job at this, worse than thermal paste. you dont need a lot of thermal paste at all, just enough to fill in air gaps on the nano meter level.