Hey, nope, you can't run 2 different series of AMD GPUs in crossfire, but you can run up to 4 different AMD GPUs of same series and of different/same model in crossfire configuration, for example: 390X can be crossfired with 390/380/370 but can't be crossfired with GPUs like HD 7950/R9 270X/ or any of the Nvidia cards. If you want to crossfire any AMD GPUs just remember "the first 2 letters (HD/R7/R9) and the Second first letter (7XXXX/2XXX/3XXX/Fury) should match with each other".