When mine has gone beserk (locked or frozen): Updated bios sometimes fix timings and become more accommodating; passing a stress test of an overclock may not tell if an application will zonk; simplify the system by turning off non-Microsoft system items in Services and described as a clean boot; use recommended memory and xmp disabled; ; check the Asus motherboard specific Forum.
My consistent problem has been too much overclock; lockup when mouse crossed window boundary. And lately, system frozen after being on overnight.
I have disabled sleep mode and hibernation.
So freezing while using Windows 10 has happened, it has not been the OS.