ASUS may not support drivers for win10 for that MB, but as long as your PC can meet the requirements for the win10, you can because win10 will install most of drivers for you. I had the z68 + i5 2500K + gtx570+ win7pro, I had no problem to upgrade the win10. So I think you should be fine as long as your pc meets the requirements.
So when you ready for upgrade, make sure 1) you uninstall the antivirus software, 2) disconnect other HDD or SSD, 3) make sure your win7/win8.1 is up to date, 4) restore or redirected personal folders to their original location, 5) one more thing make the backup your system too, that is more important, in case there is something wrong during the upgrade, you have the copy of your OS.