That's what I just built. With a couple "special" M2 ssds, Sabrent Rocket nvme....they can use ALL the bandwidth pcie v4 offers, I see 5,500 MB/s on my boot drive.
I do have a asus crosshair viii hero wifi with an 3950x ( for about 8 month), and it is a very good board and all is running flawlessly. About x570-plus I cannot say anything.