If you reset the BIOS, then you will be at mobo defaults, will need to set the Dtae/ZTime - other than that depends on the rest of your rig - i.e. if using a SSD in AHCI, then need to set drives to that, if you have a RAID set the drives to RAID, if using a discrete GPU card will need primary graphics set to PG or PCI-E, if DRAM is 1600 or better, set DRAM freq and timings (if Intel simply enable XMP), etc