From my experience so far with Overclocking the Dragon, I always had problems when the Mhz climbed up to the next processor designation, they should soon be posting a new Bios flash for the 2200+ then I'll see if my 1900+ which is presently at 2100+ can climb on up to his big brothers place with no problems. I would say until you flash the Bios for the 2200+ it will not run it, I could be wrong but I seriously doubt it.
You never know what you can do until you try.