You'll be hard-pressed to find a more versatile, high-performance enclosure.
Unless you want external drive bays. Being such a large case, it really seems like they could have found room for a couple of them. If they wanted to maximize room for radiators or optimize airflow in general, why not make them removable, or place them at the bottom, under the PSU shroud? Plenty of people still use optical drives, and external bays also allow for things like card readers, fan controllers, and other additional ports to be added. Not having the ability to add those kind of things makes this case less versatile than many others. As someone already pointed out, be quiet!'s own Pure Base 600 features a pair of removable 5.25" bays, so I would have liked to have seen something like that here as well.
I do like the case's design overall, but I don't really get why they feel the need to remove front drive bays on a case that could easily fit them.
Also, I'm not entirely fond of having all the front panel connections at the very top. That might be convenient if you keep your computer on the floor, but it's undoubtedly a bit awkward on a desk. Want to plug in headphones, or a game controller, or an external drive, or maybe charge a portable device? You'll have cords hanging down from a couple feet above the surface of your desk, looking weird and potentially getting snagged on things. It would be nice if the case were designed so that the front panel connections could be reconfigured to the bottom edge, although they would need to redesign that sloped surface they are currently located on.