Knowledge is the best antivirus.
Don't visit risky website, don't download suspicious software, don't open emails that you don't recognize.
99% of the virus' I see are installed by users who clicked on a link, accepted the system changes, and installed it themselves. The antivirus won't stop this behaviour, and does not always catch it.
AV's use a lot of system resources and do very little good. You end up with more false-positives than anything.
Windows Defender is the only one I recommend. Use a good router and don't open any ports, like RDP, directly to your system.
Don't use your Administrator account for your daily use, create a user with limited access to prevent an infection from hijacking system files. Have a good log in password.