Not a BIG problem, but it's a pretty even consensus across the board with most experienced builders that the quality of ASUS boards, and the quality of their support, is considerably better than MSI when it comes to motherboards. MSI has a much better rep in the area of graphics cards, but they've had, and continue to have, some quality control issues especially on their budget to mid grade boards. Their high end boards have had a few hit or miss issues too.
I generally recommend sticking to ASUS or ASRock, even Gigabyte, when it comes to motherboards. To each their own though. If the price difference is significant, then go with the MSI board.