k1114 :
Pc usage? A mid range gpu with an enthusiast platform doesn't say gaming to me but that's all you mention. Even with multiple top end gpus, it's not needed. Bigger ssds are cheaper than multiple small ones unless you want them for scratch which still doesn't make sense to get them that size. Again telling me it's not gaming but not stated.
Multi use. Gaming is the heaviest load but I will also use it for graphic design, writing, and other lower weight things. With the GPU, yes it's mid range but I plan on revisiting it in a year or so and see if it is still good enough. At 1080p, with frame rates between 30 and 60 (I don't notice frame dips if they stay above 30), the RX 480 should be enough.
With the SSDs, I already have one that I have Skyrim, Fallout 4, and other mod heavy games. I consider this a high use drive and want to keep it separate from other things, just in case. I know it's probably not going to be an issue, but still. The first drive will be my new system drive, with all of my programs installed and the OS, it uses about 130GB, the extra space gives me room to grow if needed. The second drive is for other games, music, videos, etc. If you have a good reason why a single 500 is better than the two 250s, I would like to hear it and make an better informed decision.