Can a 7950 3gb handle a 2 or monitor setup?

Solution
If you're gaming, then yes, but don't expect ultra settings. (and consider where the bezels would be if you only had two monitors - there's a reason it's not done. :p )

If you aren't gaming, than it's ridiculous overkill; a $150 card maximum will do what you need it to do.

If you're just gaming on one monitor and using the other two for the web or whatever, then you're fine; those monitors barely tax the GPU at all.
If you're gaming, then yes, but don't expect ultra settings. (and consider where the bezels would be if you only had two monitors - there's a reason it's not done. :p )

If you aren't gaming, than it's ridiculous overkill; a $150 card maximum will do what you need it to do.

If you're just gaming on one monitor and using the other two for the web or whatever, then you're fine; those monitors barely tax the GPU at all.
 
Solution
That's... kinda the most uninformative post you could have made. :p

First of all, the size of the screen doesn't matter; only the resolution does. A 4", 1080p screen is equally hard to render as a 36" screen.

Second, you haven't answered HOW you're going to be using these monitors. Reference my post above.