DX12 does offer a mode to game developers called "Explicit Multi-adaptor" which can potentially use two entirely different GPUs to improve performance. Here's an overview:
http://www.anandtech.com/show/9740/directx-12-geforce-plus-radeon-mgpu-preview
I remember a Microsoft presentation a while back which showed a demo run with improved FPS from using an Intel onboard GPU working together with a relatively high end discrete GPU, when compared to just the dicrete GPU alone. I thought would never make any tangible difference. That was, of course, a closed tech demo by Microsoft, so not a trustworthy indication of where things are heading.
Having said all that, there are only a couple of titles which actually implement Explicit Multi-adapter and in those, with the huge performance difference between a 750ti and 390, you're very unlikely to see worthwhile gains in even those few titles. So while technically possible, it's not really practically worthwhile.