Yes you can. I have the same GPU but overclocked +135/+180mhz (+20% performance gain in The Witcher 3).
My settings:
1600x900
FXAA
Textures: Ultra
Water quality, Number of Background Characters and detail level: High
Grass density, Foliage visibility range and terrain quality: Medium
Shadows: Low
All post processing settings enabled. The game usually runs 30-45 FPS. Without overclocking you will probably get lower framerates but you can still run the game easily.