Yes it will support.... but the PCIe slot in your mobo will more likely be a PCIe 1.0 or PCIe 1.1 slot. And all the new GPUs will be either PCIe 2.0 or PCIe 3.0 compatible cards. They are backward compatible and they can work in PCIe1.0/1.1 however these new cards are bandwidth limited when they run in PCIe 1.0/1.1 slot meaning you can't get the full performance out of these new cards in PCIe 1.0/1.1 slot.