If it physically fits and the psu is large enough to power the system, then it should work. That said, your mobo/cpu/bios is right around the time when changes to bios from legacy to uefi were being implemented and there was much confusion as to why new cards didn't work on the new bios. The biggest issues were with the 750ti, the Maxwell cards were a redesign in thinking, half the power and ability at twice the performance of the older generation nvidia cards. So depending on your particular bios, you may or may not have any issues, but if you do, it's a known issue and not specific to your setup. There are workarounds, tweeks etc you may need to implement, including a flash of the latest bios if needs be...