Well, there's this... http://www.gamespot.com/articles/directx-12-can-combine-nvidia-and-amd-cards/1100-6425565/ Who knows if it will actually happen though.
Games like 'Civ: Beyond Earth' - when played under crossfire - are now splitting the screen into separate rendering pieces using AMD Mantle, and what with AMD APU's already being able to play nice with multiple different GPUs, AMD might someday support different GPUs working together in crossfire. Knowing AMD though, such an implementation would be buggy as hell on the drivers end.