NO Core-i CPUs will work with that motherboard, it is too old. Core 2 duo and Core 2 quad models are probably your best choices although you'll need to pay attention to what BIOS version your board has based on the support for specific CPU models only WITH a specific BIOS version having already been installed. If you are looking to buy this board and don't have it already, I'd decline. It's old enough by now that most of it's useful life is probably already gone. There are much better options than a platform that is already more than ten years old.