Yes it will you just need to install the latest bios first. As for potential problems, despite the promise of 4 generations of compatibility on AM4, support for new CPU's on older boards isn't also seamless. It can sometimes be hit or miss whether it's going to work perfectly normally without issue. This is particularly true on the 300 series boards.
You do have a nice board though, I would have thought you were one of the least likely to have a problem.