Yes you can, you just may suffer on performance, depending on the game.
SSDs generally improve loading times, less so FPS and in game performance (not considerable at least).
@androbourne
Fade to Silence. It will be releasing on 14th Dec (Early Access on Steam). Someone asked them if it is just a placeholder and they said no. It is really weird because they require low end 2GB VRAM GPU and pair it with 12GB RAM.