I understand there is likely no definitive answer, but I'm noping for a usually, or generally not. My old old computer (as opposed to just my old) died not long ago, seems the PS died and took out the rest, it won't even post even with a new PS. I didn't use it a ton, but some, and would like something in it's place. I'm seeing some used "flat" (5X16X16?) desktops, common in the office and wondering if I could take the MOBO etc out and use them in the old tower? I'm always swapping drives, this and that and a mid tower really works better for me. And to the best of my knowledge, the flat ones (and yes, I know you can stand them on end, but for sake of ID) don't have much room for added drives etc.