Win7, DirectX 11 and prior were setup for SLI compatibility, so getting amd and nvidia to play nice was next to impossible without some registry work and changes and keeping the 2 cards and their drivers as seperate as possible, and even then it went from impossible to iffy since nvidia and amd hate each other with a passion and each feels like they should have priority.
Win10 and it's native DirectX 12 changed that, dropping SLI support and adopting MGPU (multi - gpu) as the base. This effectively removed all restrictions to recognition of card, type, model, size etc that SLI needed.
So as said, yes, it's very possible, but as also said, it's not plug and play, you'll still need to dive into the settings and sort out what goes where, which app uses what card etc.