Yes it can, but don't plan on oc'ing those babies, you may surpass your psu. Also please be aware of what games you are playing and if they support crossfire. Sometimes you can get worse performance or screen tearing by using crossfire on games that just simply don't support it. From watt (see what i did there) you are looking at, those gpu's will pull 450-500 watts where if you get a better gpu such as a 1070 or 1080, not only is the power draw nearly half that, but you wont have to worry about crossfire or sli game compatability. My advice, just get the best single card in your budget.