FatheredPuma81 :
I wanted to do some tests etc to see what my GPU would do at the lowest possible clock MSI afterburner would allow and I wanted to change it around mid game or in parts that are stressful to an overclock (that is stable I have tested it) that is the max on msi afterburner.
This is a clock from 275 (core) and 200 (mem) to 715 (core) and 520 (mem).
Can this harm my GPU?
The underclock at 275/200 is a zero problem, the overclock at 715/520, as long as it's a stable overclock and you're not experiencing any crashes should be OK.
However I personally would activate the overclock before opening the game instead of mid game, just for gaming convenience, but I don't see it would hurt the GPU to do that.
I am curious as to why you want to underclock the card, save electricity maybe? as it is going to run a lower clock until the higher clock is needed automatically anyway?
But if all you really want to know is, "Can this harm my GPU?"
Probably not, but there are no definite guarantees anytime overclocking enters the picture, whether it is a GPU or CPU, Understand?