Utilizing single channel, it depends on the task and the memory requirements - again a little too simplistic.
If the task in question requires <8GB RAM, then the 2400MHz may have some gains (marginal likely, but still).
If it requires >8GB, then the 16GB 2133MHz is the smarter of the two options.
Single channel rarely makes sense though.
Most people assuming if they run 1x8GB (or 1x16GB etc) now, it's easy to drop a second in there in future.
In theory, that's correct. In practice, even identical models/speeds *can* be problematic (not always). That's why RAM is sold in "kits" of 2xWhateverGB or 4xEtc. They're guaranteed to work together, tested at the factory.