You can remove it and connect via some other means yes, it's often been done with other brands of external HDD. You can even put it inside a different enclosure which are available in PC stores & online.
The problem often encountered though is the HDD interface being a proprietary one, not SATA or IDE as we know it. That's certainly the case with newer external HDDs. You won't know until you get the drive out of it's Lacie enclosure.