Please confirm you've checked everything, i.e. the usual culprits. Bent Pins, secure connections, the correct connections made for the case panel, try using one stick of RAM to boot first, assuming your RAM is compatible with your sys, etc & so on. I know I've left out some things but this is a rather basic question, with, very little info provided by you in regards to your sys (which is usually the case with those who ask the same questions btw).
The title says "Can't Power On System in Case". Does this infer that you were able to power it on and get it to post before you put it in your (possibly new?) case? Is your PSU compatible with your system (new system with old PSU maybe)? Is it set to the right voltage for your country...