If the case has no cable management, swapping PSUs takes about 10 minutes when you know what you are doing. In cases where all the wires are routed behind the motherboard, it can take well over half an hour to untie all the wires, untangle them, thread them out through cut-outs, pull the new cables through and tidy everything up.
All the PSU connectors are keyed, which should make it nearly impossible to connect them incorrectly without having to use substantial force.