The problem with that is, you are leaving a significant amount of performance on the table by using a single DIMM than you would be using a dual DIMM configuration because with that single DIMM you will not have dual channel performance, which effectively doubles the bandwidth of the memory bus.
On ANY system that supports dual channel memory architecture, it SHOULD be employed if at all possible. The only possible reason for going with a single DIMM would be if it was a platform that didn't support dual channel memory architecture OR if you had plans to add another 32GB later on down the road, and even then it wouldn't be a very good, or wise plan, because there would be no guarantees that adding a second unmatched stick (Unmatched...