First off, who is your ISP, and do they force software on your PC? Or have you recently installed a software for remote access or screen sharing?
I have Comcast, and for initial setup, they force an install of some really bad software for "support reasons." It's a special remote control software so that their support people can help mainstream users with no technical expertise. The problem with their software is that it causes many games to crash. (It's the whole screen sharing driver thing that causes the crashes.) It is impossible to completely remove, too. I've had to rebuild my machine twice because of their installers installing that crap software on my machine. I have since learned, and when I move, I build a backup system and use that to do the software install during the cable internet installation. They may have changed this policy in the last year, but they were still enforcing that software install as of my last move in September of 2013.
If you have not installed any sort of screen sharing software, then you'll have to try these steps:
1. make sure your graphics drivers are up to date. They might even be damaged, so try a reinstall
2. check out your OS files. With Windows, go to the Run box and type in "sfc /scannow" and let it run. It takes a while. If your OS installed on that SSD, then it will probably take about an hour. If it is installed on the 1TB hard drive, it might take 4-5 hours.
Now for hardware:
3. run a scan on your hard drives for cad sectors. From the command prompt, type "chkdsk c: /r" and it will say something about exclusive locking to the drive and that it can't do it right now, and ask if it should schedule a scan for the next reboot. Say yes, and then reboot. Do this for all drives.
4. Try removing your graphics card and run off the integrated graphics. It will hurt performance, yes, but if it stays stable, then you'll know it is your graphics card.
5. if it still crashes with integrated graphics, try putting the R9-280X back in and make sure your integrated graphics is disabled in the bios. It could be that the integrated graphics is causing an error, or that the integrated graphics is bad on the processor. This is a long shot, but possible, so it is good to check.
6. Is this still doesn't work, it may be memory, motherboard, or processor problems. Memory is more likely than the processor, so check out the memory first. Run the system with just one DIMM at a time.
7. test the memory with a known good DIMM (determined in step 5) in every memory socket, one at a time. The motherboard may or may not operate with memory in the wrong sockets, but it is still good to check and make sure. If it operates, but later crashes, then it is the socket, and you'll need to replace your motherboard.
8. Finally, if all else fails, test the processor. Run a benchmark that is very processor intensive, but without touching other subsystems. I believe Intelburntest (http://www.majorgeeks.com/files/details/intelburntest.html) is good for that.
9. if you still can't find the problem, It's going to get complicated. I'll give you next steps after you try everything above.
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