No, the motherboard layout is similar to a m-atx with a bit of a modified pcb, but that's not the problem. The problem lies in the power supply connection, it is a non-standard layout in the form of a 10 pin connection rather then the standard 24 pin connection.
In order for it to work with a standard psu, you would have to find either a custom cable adapter, or make one yourself by identifying the values on each pin and then soldering to the correct pin on the atx psu. Overall not a goof method as this may increase load on the connections to above spec values and may be a fire hazard.
The system comes with a 180w psu, I think, so no gpu upgrades either unless its the gt1030 and you leave the side panel open.