There is no definitive answer to this. Load Line Calibration effectively means how aggressively the motherboard will try to maintain the CPU voltage.
None of these figures have any base in fact this is just purely as an illustration: Lets say for example your machine will BSOD if the voltage hits <1.1v under load. So if your voltage is set to 1.112v for example and your LLC is set to low, then possibly the voltage may drop to 1.099 causing your machine to BSOD. So rather than increasing your voltage to 1.150 you might increase your LLC setting to medium. This could then for example cause your voltage drop to only be 1.107 meaning your machine will not BSOD.
The answer to your question is to experiment. If your machine is stable at...